Read the latest clinical trials for Stem Cell injection for Lower Back Pain

Clinical trials showing the effectiveness of Stem Cell Injections for Lower Back Pain. Most patients in these studies had significant pain relief. Some patients also revealed reversal of disc degeneration. No patients had any serious complications. Dr.Atluri is delivering similar results in his patients in Cincinnati. Stemcures is also conducting clinical trials with stem cells in patients who are suffering from lower back pain. Since stem cells are a new development in medicine, there is not an abundance of data. However, the data that exists shows that stem cell injections into the disc results in pain relief and improvement in function.

Clinical Trials 1

In this landmark study by Pettine’s group, 26 patients with lower back pain had their lumbar discs injected with stem cells which were extracted from the bone marrow. After 2 years, 21 patients (81%) avoided surgery and had pain reduction of 71%. Their function improved by 64%. Additionally, 40% patients had improvements seen on the follow up MRI’s. No complications were reported.

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Study 2

In this study by Orozco, 10 patients with lower back pain had their discs injected with expanded bone marrow cells. After one year, 9 out of the 10 patients reported significant pain relief and improvement in life quality. Even patients with sciatica reported pain relief. Patients also had increased water content in the disc when checked on MRI a year later, indicating disc regeneration. No complications were reported

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Study 3

In this study by Centeno’s group, 5 patients with lower back pain had their discs injected with cultured bone marrow stem cells. These patients were followed for 4-6 years. All patients self-reported overall improvement, as well as improvement in strength, post stem cell treatment, and four out of five patients reported improvement in mobility.Most of them also saw a decrease in the disc protusions on the follow up MRI’s.

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Study 4

In this study umbilical cord stem cells were injected in the discs of 2 patients suffering from lower back pain. Both patients reported significant pain relief for at least 2 years when the study period ended. One patient exhibited increased water content in the disc when MRI was checked 2 years later. No complications were reported.

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Clinical Trial 5

In this study, fat stem cells were removed by liposuction from 15 patients and concentrated. This concentrate was injected into the lumbar discs of patients suffering from lower back pain. After 6 months, majority patients reported significant decrease in pain along with increase in range of motion. No complications were noted.

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Study 6

In this review, Oehme’s group analysed the available animal and human trials regarding disc injections of stem cells and concluded that, “The intradiscal administration of such cells may offer patients failing conservative treatments a less invasive treatment option than open surgery.

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Study 7

Wu’s group performed a metaanalysis of all the clinical studies regarding stem cells injection into discs and concluded that, Cell-based therapy is for patients who have discogenic low back pain associated with improved pain relief and Oswestry Disability Index.

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Study 8

Centeno’s group followed 2372 patients who had stem cell injections in various joints for 2.2 years. They reported no serious side effects.

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Study 9

Autologous bone marrow concentrate intradiscal injection for the treatment of degenerative disc disease with three-year follow-up.

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